Gene Silencing by U1 Adaptor

Gene Silencing by U1 Adaptor

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Credit: KENNETH EWARD/SCIENCE PHOTO LIBRARY

Caption: U1 Adaptors are a nanotechnology used for gene silencing - the prevention of protein production by a particular gene of interest. Unlike antisense and RNA interference gene silencers, U1 adaptors work at the spliceosome: macromolecular assemblies inside the cell nucleus that process pre-mRNA transcripts prior to export into the cytoplasm and translation into proteins. Specifically, a U1 adaptor (orange-red) can be tailor-made to bind pre-mRNA (blue) from a specific gene and tether it firmly to the U1 snRNP component of the spliceosome, thereby gumming up the works. This action prevents the addition of a poly(A)-tail to the pre-mRNA, which leads to rapid degradation by RNase enzymes and prevents its use in protein synthesis.

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Keywords: animation, artwork, cgi, digital, digitally generated, drawing, epigenetic, gene regulation, gene silencing, graphic, illustration, model, molecular, molecular model, molecule, nanotech, nanotechnology, pre mrna, pre-mrna, protein production, ribonucleic, ribonucleic acid, rna, science, scientific, snrnp, spliceosomal, spliceosome, tech, technology, u1, u1 adaptor, u1 adaptors, u1 small nuclear ribonucleoprotein, u1 snrnp, u1 spliceosomal rna

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