RANKL, Model

RANKL, Model

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Credit: SCOTT CAMAZINE/SCIENCE PHOTO LIBRARY

Caption: Ribbon molecular model of RANKL (Receptor Activator for Nuclear Factor kappa B Ligand), also known as TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and ODF (osteoclast differentiation factor). RANKL is a molecule important in bone metabolism. This natural and necessary surface-bound molecule activates osteoclasts, cells involved in bone resorption. Overproduction of RANKL is implicated in a variety of degenerative bone diseases, such as rheumatoid arthritis and osteomyelitis. In this representation, the interior of the molecule is shown in shades of blue and violet, while the more peripheral portions of the molecule are shown in shades of red, orange and yellow.

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