Gene therapy: microinjection of DNA into T-cell

Gene therapy: microinjection of DNA into T-cell

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Credit: PHILIPPE PLAILLY/SCIENCE PHOTO LIBRARY

Caption: Gene therapy. Scientist performing DNA micro- injection technique, using a micropipette to introduce a corrective gene into a human T- lymphocyte (a white blood cell). A video micrograph showing the tip of the pipette & cell material appears on screen; the pipette is controlled by the joystick in the woman's right hand. This case involved a young girl whose immune system had collapsed because of her failure to produce an enzyme, adenosine desaminase (ADA), which controls the maturation of T-cells. Lymphocytes collected from her are treated with the gene that expresses ADA & the modified cells re-injected into a vein. Results are very good.

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Keywords: adenosine desaminase, biochemistry, biotechnology, defect, dna research, enzyme deficiency, gene therapy, genetic, genetics, injections, micro-injection, micro-injection of, t-cell, treatment

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