Cleavage of DNA by designed enediyne: 3rd of 4

Cleavage of DNA by designed enediyne: 3rd of 4

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This image is part of the feature Enediynes

Credit: K.C.NICOLAOU ET AL, SCRIPPS RESEARCH INSTITUTE/SCIENCE PHOTO LIBRARY

Caption: Action of designed enediynes: Last of 4 molecular graphics showing the cleavage of DNA by a synthetic enediyne (at top). A number of these compounds have been designed by K.C. Nicolaou & colleagues at the Scripps Research Institute, California, to mimic the selective anticancer properties of more complex naturally- occurring relatives. The enediynes are designed with functional groups that target the DNA & trigger a series of reactions that result in its breakage. The DNA model was produced by J.Macke for a video by M.Pique entitled ENEDIYNES: CHEMICAL WARFARE AGAINST CANCER.

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Keywords: anticancer drug, bioengineered, bioengineering, biotechnology, cancer, cancer research, dna cleavage, double helix, drug, drug design, drugs, enediyne, enediyne chemistry, genetic, genetics, manufacture, pharmacology, production

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