Hybridoma cell, TEM

Hybridoma cell, TEM

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Credit: STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY

Caption: Hybridoma cell, coloured transmission electron micrograph (TEM). This is a man-made hybrid cell used in the production of monoclonal antibodies. Hybridomas are produced after injecting a mouse with a foreign substance (antigen), harvesting its antibody-producing white blood cells (plasma cells) and fusing them with myeloma cells (cancerous plasma cells). Fusing plasma and myeloma cells allows hybridomas to grow indefinitely in culture. The hybridoma cells are cloned and tested for the desired antibody. The desired clones are grown in culture and their antibodies harvested. To the right of the nucleus (white/brown) of this cell are mouse leukaemia virus particles (green). Magnification: x7000 at 10 cm wide.

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Keywords: antibodies, biological, biology, biotech, biotechnology, cancerous, coloured, culture, false-coloured, hybrid, hybridoma cell, immortal, immunology, infected, intracellular, leukemia, malignant, medical, medicine, microbiological, microbiology, monoclonal antibody, mouse leukaemia virus, myeloma, nucleus, plasma cell, production, tem, transmission electron micrograph, transmission electron microscope, viral, virology, viruses

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