Marburg virus particles, coloured transmission electron micrograph (TEM). This tubular virus consists of an RNA (ribonucleic acid) core enclosed within a helical nucleocapsid. The nucleocapsid is itself enclosed in a glycoprotein envelope. Some of the particles are showing the characteristic shepherd's crook shape. This virus causes Marburg haemorrhagic fever in humans and non-human primates. Symptoms of the rare disease, which is often fatal, include fever, muscle pain, rash, diarrhoea and haemorrhage. The virus was first documented in 1967 when there were simultaneous outbreaks of haemorrhagic fever in laboratories in Marburg and Frankfurt, Germany and Belgrade, Yugoslavia. The outbreak was traced to vervet monkey tissue used in research. Magnification: x60,000 at 10 centimetres wide.
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