Murine norovirus with antibody fragments

Murine norovirus with antibody fragments

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This image is part of the feature Modelling Nature Deadly Machines

Credit: THOMAS SMITH/DANFORTH CENTER/SCIENCE PHOTO LIBRARY

Caption: Murine norovirus (MNV) with antibody fragments, computer model. This image was created using molecular modelling software and data from cryo- electron microscopy. The image shows the outer protein shell of the virus (yellow, green), known as the capsid. It is covered with antibody fragments (light to dark blue) known as Fabs (antigen binding fragments). MNV belongs to the norovirus group of viruses, which are a major cause of non-bacterial gastroenteritis in humans. MNV infects only mice. Cryo-electron microscopy images specimens at a temperature of minus 150 degrees Celsius. It fires beams of electrons at multiple angles creating 'slices' of data that are reconstructed into 3-D models on computer.

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