Human rhinovirus, computer model

Human rhinovirus, computer model

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Caption: Human rhinovirus (HRV) with intercellular adhesion molecule 1 (ICAM-1), computer model. This image was created using UCSF Chimera molecular modelling software and data from cryo-electron microscopy. It shows the protein shell of the virus (red, yellow, purple), known as the capsid, with ICAM-1 molecules (light blue) attached. HRV is the virus that causes the common cold. ICAM-1 is a protein located on the surface of leukocyte and endothelial cells. It binds strongly to HRV. Cryo-electron microscopes fire multi-angled beams of electrons at specimens that are kept at minus 150 degrees Celsius. The microscope collects 'slices' of data that are constructed by programs, such as UCSF Chimera, into 3-D models.

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