TEM of fibrils in mad cow disease

TEM of fibrils in mad cow disease

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Caption: Transmission electron micrograph (TEM) of negative stained fibrils in an extract of fresh brain from a cow infected with bovine spongiform encephalopathy, a form of transmissible, slow virus encephalopathy. Human slow virus encephalopathies include Kuru, Creutzfeldt-Jakob disease and Gerstmann-Straussler syndrome. The agents causing these diseases form a group of virus-like organisms called prions. The fibrils are believed to be aggregations of the major proteins of the infectious agents themselves. Magnification: x205,000 at 6x8-inch size, x36,300 at 35mm size.

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Keywords: biology, bovin spong. enceph., bovine spong. enceph., encephalopathy, fibrils, microbiology, prion, prions, slow virus, slow virus encephalopathy, transmissible encephalopathy, virology, virus-like

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