LM of brain in Alzheimer's disease - senile plaque

LM of brain in Alzheimer's disease - senile plaque


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Light micrograph of human brain tissue in Alzheimer's disease, showing a senile plaque (pale area in centre), a characteristic histological feature of the disease. Alzheimer's disease is a form of progressive dementia; the brain is smaller than normal, with degenerative changes affecting the frontal and temporal lobes. Senile plaques are tangled masses of filaments & granules, often centred around an area of amyloid. The main other feature of Alzheimer's disease is the formation of neurofibrillary tangles, masses of thickened filaments in the cytoplasm of neurons (nerve cells). Magnification: x130 at 35mm size.

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