Brain tissue with Alzheimer's disease

Brain tissue with Alzheimer's disease

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Credit: DR. M. GOEDERT/SCIENCE PHOTO LIBRARY

Caption: Alzheimer's disease brain tissue. Light micrograph of a section of hippocampal brain tissue affected by Alzheimer's disease. Characteristic features of Alzheimer's disease are seen here: a neuritic amyloid plaque (upper left) and nerve cells containing neurofibrillary tangles (black triangles). Tangles in nerve cells lead to the main symptoms of Alzheimer's: memory loss, dementia and death. The tangles are made up mainly of tau protein, which becomes filamentous and pathogenic due to abnormal interactions with sulphated glycosaminoglycans. Stained with anti- heparan sulphate antibody (brown) and anti-tau antibody (black). Magnification: x70 at 35mm size.

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Keywords: alzhe, alzhei, alzheimer's, alzheimer's disease, alzheimers disease, condition, dementia, disease, disorder, healthcare, light micrograph, medical, medicine, nerve cell, neuritic, neuritic plaque, neurofibrillary, neurofibrillary tang, neurofibrillary tangle, plaque, plaques and tangles, tangle

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