Micrograph of the wall of the human intestine

Micrograph of the wall of the human intestine

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Caption: Light micrograph of a part of the wall of the human small intestine in Crohn's disease, showing a granuloma located between the muscle layers. Crohn's disease is a chronic inflammatory disease of unknown cause that mainly affects the small intestine, although the colon & anus may also be involved. Affected gut becomes thickened & pitted with fissured ulcers. Granuloma formation occurs throughout all layers of the gut wall. This oval granuloma contains macrophages and giant cells (dense purple stain) as well as smaller, darkly- stained lymphocytes. One consequence of long- standing Crohn's disease is fibrosis that may cause bowel obstruction.

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Keywords: condition, crohn's disease, crohn's granuloma, disease, disorder, giant cells, granuloma, healthcare, ileitis, medical, medicine, of crohn's disease, regional

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