Cancer diagnosis: Drs Tarin & Matsumura with gel

Cancer diagnosis: Drs Tarin & Matsumura with gel

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Credit: JAMES KING-HOLMES/SCIENCE PHOTO LIBRARY

Caption: Early detection of cancer: a red pen marks a band on a DNA sequencing autoradiogram confirming a bladder cancer. Scientists in the Nuffield Department of Pathology at John Radcliffe Hospital, Oxford, have developed a method for the early detection of cancer before it spreads (metastasizes) around the body. They examined the gene responsible for a glycoprotein, CD44, which determines the mobility of lymphocytes, comparing its activity in cancerous & normal tissue. Results revealed a significant variation in the quantity & type of CD44 products that allowed them to differentiate between normal tissue, benign tumours & cancers. mRNA from a section of the gene was amplified using PCR & CD44 products analysed by gel electrophoresis & blot hybridisation.

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Keywords: autoradiogram, cancer, cancer and, cancer research, diagnostic medicine, dna, early diagnosis, healthcare, medical, medicine

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