Monoclonal antibody: p53 tumour suppressor

Monoclonal antibody: p53 tumour suppressor

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This image is part of the feature P53: Cancer Protein

Credit: PHILIPPE PLAILLY/SCIENCE PHOTO LIBRARY

Caption: Experimental cancer therapy: bottle containing the monoclonal antibody p53, a tumour suppressing protein. A normal p53 gene becomes activated in response to the threat of radiation & carcinogenic chemicals. The protein it expresses causes cell division to be suspended, allowing any chromosome damage to be repaired & not passed on to the daughter cells to cause cancer or cell death. This protective function is disabled if p53 becomes mutated or its proteins neutralised by viruses or cancer gene products. Administering cloned p53 may restore this mechanism & perhaps potentiate other, more conventional, forms of cancer therapy.

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Keywords: anti onco-, anti-oncogene, cancer, cancer research, cancer therapy, gene, healthcare, medical, medicine, monoclonal antibody, mutation and, p53, p53 mutation, p53 tumour suppressor, tumour supressor gene, tumourigenesis

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