Down's syndrome. Young girl with Down's syndrome sitting on a swing in a play area. Down's syndrome is a chromosomal abnormality resulting in mental handicap and a characteristic physical appearance. The genetic defect concerns chromosome number 21, as there are three of these chromosomes instead of the normal two. For this reason the disorder is also called trisomy 21. The main physical features are slanted eyes, a flat nose on a round head and abnormalities of the palms of the hands and the soles of the feet. Children with Down's syndrome may have an I.Q. of anywhere between 30 and 80.
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