Blue sclera. Close-up of the eye of a 6-month-old baby girl, showing blue colouration in the sclera (the white of the eye). Blue sclera may be a sign of osteogenesis imperfecta, a genetic condition in which the bones fail to develop properly and are brittle and prone to fracture. In osteogenesis imperfecta the blue colour results from abnormal thinness of the sclera. Blue sclera may also occur in the rare genetic bone disorder hyperphosphatasia, and in the genetic skin disease pseudoxanthoma elasticum.
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