Philadelphia chromosome

Philadelphia chromosome

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Caption: Philadelphia chromosome. Coloured light micrograph of two chromosome pairs with a genetic defect that causes chronic myelogenous leukaemia (CML). Pairs of chromosomes comprise a paternal and a maternal chromosome. From left is a normal chromosome 9, a larger defective chromosome 9, a normal chromosome 22 and a smaller defective chromosome 22. This translocational defect resulted from an exchange of material between the two defective chromosomes. The four chromosomes have replicated and will pass the defect to a new cell. The defective chromosome 22, when present in a bone marrow stem cell, leads to the increased white blood cell count in CML.

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Keywords: 22, 9, blood cancer, bone marrow, chromatid, chromatids, chromosome, chromosomes, chronic myelogenous, cml, coloured, condition, cytogenetics, defect, defective, disease, disorder, genetic, genetics, healthcare, hereditary, inherited, leukaemia, leukaemic, leukemia, light micrograph, lm, medical, medicine, myelocytic, myeloid, ph1, philadelphia, precursor, replicate, replicated, sister, stem cell, translocational

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