Light micrograph of cervix revealing carcinoma

Light micrograph of cervix revealing carcinoma

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Caption: Light micrograph of a biopsy section through the human cervix revealing carcinoma-in-situ (severe dysplasia, CIN 3). The cervix is lined by a stratified squamous epithelium. Normally, all cell division is confined to the basal epithelial layer (centre of image). As a cell matures & rises up the layers, its cytoplasm expands & nucleus shrinks in size - a normal superficial cell is flat, with a small nucleus & a large cytoplasm. In carcinoma-in-situ the gradual stratification in cell maturation seen in normal epithelium is absent: dysplastic (abnormal) cells extend throughout the entire epithelium. The basement membrane remains defined & intact.

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Keywords: carcinoma-in-situ, cervical smear, cervix, cin 3, cin 3 cervix, condition, disorder, dysplasia, female reproductive system, gynaecological, gynaecology, gynecology, healthcare, histology, medical, medicine, mitotic figures, reproduction pathology, severe, severe dysplasia

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