Immunofluorescent LM of active macrophages

Immunofluorescent LM of active macrophages

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Credit: NANCY KEDERSHA/SCIENCE PHOTO LIBRARY

Caption: Active macrophages. Immunofluorescent light micrograph of active macrophage white blood cells producing cytokine proteins. The central cell has multiple nuclei (blue). Vaults are red and TIA-1, a protein which stops cytokine overproduction, is yellow/green. Cytokines are released by one cell population in order to influence another. If too much cytokine has been made, TIA-1 stops its production by binding to the mRNA (messenger ribonucleic acid) that codes for it, forming stress bodies (yellow). These macrophages have been activated by exposure to a mock bacterial infection. Macrophages help to kill invading organisms. Magnification: x200 at 5x7cm size.

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Keywords: active, anatomy, cells, cytokine, defence, human body, immune, immunofluores, immunology, infection, light micrograph, macrophage, macrophage response, macrophages, mouse macrophages, raw 264.7, stress body, system, tia-1, vault

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