Fluorescence micrograph of normal micrograph

Fluorescence micrograph of normal micrograph

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Caption: Normal result in the prenatal screening of Down syndrome: fluorescence in situ hybridisation (FISH) micrograph of chromosomes from sampled cells of a normal fetus. FISH is being applied to prenatal detection of Down syndrome (Trisomy 21). Here, chromosome 21 DNA appears yellow when stained with fluorescein; the remaining cellular DNA appears red from staining with propidium iodide. Normal cells with 2 copies of chromosome 21 usually show 2 yellow domains; Down syndrome cells have 3 copies of chromosome 21 & usually show 3 yellow areas. Variance due to domain overlap is corrected by statistical methods.

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Keywords: anatomy, chromosome, chromosome 21, chromosomes, down's syndrome, downs, fish, fish technique, fluorescence in situ hybridisa, genetics, human body, normal chromosomes, pre-natal tst

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