Doubled chromosome, SEM

Doubled chromosome, SEM

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Credit: ADRIAN T SUMNER/SCIENCE PHOTO LIBRARY

Caption: Doubled chromosome. Coloured scanning electron micrograph (SEM) of a diplochromosome after treatment with etoposide. Chromosomes normally consist of two identical chromatids joined at a centromere, diplochromosomes have four chromatids. Etoposide is a drug that is used to treat some types of cancer, mainly testicular and small-cell lung cancer. It prevents malignant (cancerous) cells from spreading by interfering with cell division mechanisms, eventually causing cell death. Diplochromosomes are a result of etoposide interference, as chromatids are not separated after replication as they normally would be. Etoposide also physically damages chromosomes. Magnification: x16,800 when printed 10cm wide.

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Keywords: antineoplastic, arm, arms, biological, biology, cancer, carcinogen, carcinogenic, centromere, chromatid, chromatids, chromatin, chromosome, coiled, coloured, condensed, cytotoxic, deoxyribonucleic acid, diplochromosome, dna, doubled, drug, etoposide, false-colour, false-coloured, gene, genes, genetic material, genetics, heredity, images, information, inherited, lethal, magnified image, medication, microscopic photos, mitotic inhibitor, mutagen, mutagenic, mutant, mutation, pair, polyploid, polyploidy, scanning electron micrograph, scanning electron microscope, sem, subjects, treatment

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