Illustration showing an anorexic (loss of appetite) male with cachexia (severe malnutrition) due to cancer which causes a loss of appetite. The large molecule in front is megestrol acetate (megace) which promotes weight gain and stimulates appetite. Prolonged use of megestrol acetate can cause overproduction of cortisol (shown as the skeletal molecule behind the anorexic male) in the body and can lead to Cushing's syndrome when the body is exposed to high levels of cortisol.
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