Caption: Dasatinib leukaemia drug binding to its target, the enzyme Bcr-Abl tyrosine kinase. This enzyme is produced by a genetic mutation, the swapping of parts of two chromosomes, leading to the formation of the oncogene (cancer-causing gene) Bcr-Abl, which produces a constantly-active version of normal Abl tyrosine kinase. This causes chronic myelogenous leukaemia (CML), a cancer of white blood cells. The drug Sprycel (Dasatinib) works by binding to the active site of the Bcr-Abl enzyme, producing a change in shape that prevents the enzyme from functioning. This causes the death of cancerous cells expressing the enzyme. Sprycel is marketed by Bristol-Myers Squibb.

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Keywords: active site, anti-cancer, anticancer, bcr-abl, binding, biochemical, biochemistry, cancer, cancerous, chemical, chemistry, chemotherapy, chromosomal, chronic myelogenous leukaemia, cml, conformational change, dasatinib, designed, diagram, drug, drug design, enzyme, fusion gene, fusion protein, genetic, genetic disorder, genetics, inhibition, inhibitor, leukaemia, leukemia, moa, mode of action, model, molecular, molecule, mutant, mutated, oncogene, philadelphia chromosome, protein, rational, ribbon, ribbons, sprycel, targeted, tki, translocation, tyrosine kinase

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Dasatinib leukaemia drug action

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