Influenza proton pump, molecular model

Influenza proton pump, molecular model

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Caption: Influenza proton pump. Molecular model showing the protein structure of a proton pump from an influenza virus. Proton pumps are membrane proteins that move protons across a cell membrane. This is tetrameric proton channel M2 in complex with the inhibitor drug rimantadine. In the closed state, four tightly packed transmembrane helices define a narrow channel. Rimantadine binds on the lipid-facing side of the channel, stabilizing the closed conformation. It is thought that drug-resistant mutations may counter this effect. This proton pump is from an H3N2 influenza A virus.

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