Beta secretase inhibitor, molecular model

Beta secretase inhibitor, molecular model

C015/1976 Rights Managed

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Caption: Beta secretase inhibitor, molecular model. The inhibitor molecule (centre, also shown in C015/1977) is bound to the beta secretase enzyme (partially seen). This enzyme, of the type known as aspartic-acid protease, is also known as beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1). It is a transmembrane protein that is thought to play a role in Alzheimer's disease through the build up of amyloid plaques in the brain. Drugs that inhibit this enzyme may help slow the progress of the disease.

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