Notch transcription, molecular model

Notch transcription, molecular model

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Credit: RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY

Caption: Notch transcription. Molecular model showing a strand of DNA (deoxyribonucleic acid) being acted upon by various proteins and other molecules. The main proteins are transcription factor CSL (blue) and the Notch 1 intra-cellular receptor or domain (white). Both are bound to a specific DNA sequence named HES1 promoter (Hairy and Enhancer of Split-1). The CSL-Notch interaction is stabilized by interaction with transcriptional co-activator Mastermind-like protein (MAML, orange, lower left). This transcription process is part of a wider cell signalling system called the notch signalling pathway.

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