Anaesthetic inhibiting an ion channel

Anaesthetic inhibiting an ion channel

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Caption: Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres, lower left and right) bound to a pentameric ligand-gated ion channel (pLGIC, grey and blue). Propofol is used for inducing and maintaining general anaesthesia. pLGICs are targeted by general anaesthetics such as propofol which bind to the extracellular interface between the channel's five monomers (subunits) and inhibit its action.

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