Caption: Animation of incomplete calcium ion reuptake due to abnormal sarcoplasmic reticulum (SR) in a heart cell affected by dilated cardiomyopathy (DCM). Impaired function of the SERCA calcium ion pumps (spikes in foreground) is a characteristic molecular defect in DCM heart cells. The inefficiency of the SERCA means that calcium ions (white dots) are not fully cleared from the intracellular space, preventing a full relaxation of the heart cells at diastole. This is evident in the blue ECG trace (top right) which shows an incomplete relaxation phase.

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Keywords: abnormal, atp, atpase, beat, beating, biological, biology, ca+, ca2+, ca2+-atpase, calcium, calcium ions, cardiac, cardio, cardiology, cardiomyopathy, cycle, cycles, cyclic, cytosol, dcm, defect, defective, diastole, dilated, disease, diseased, ecg, electrocardiogram, heartbeat, heartbeats, human biology, impaired, impairment, inefficiency, inefficient, intracellular, ion, ions, medical, medicine, mitochondrion, molecular, muscle, myocardiocyte, myocardiocytes, myopathy, na-ca exchanger, phase, phases, physiological, physiology, pump, pumping, pumps, re-uptake, regulating, regulation, relaxation, sarcolemma, sarcoplasmic reticulum, serca, sr, systole, unhealthy

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Dilated cardiomyopathy, animation

K003/8652 Rights Managed

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Duration: 00:00:55

Frame size: 640x480

Frame rate: 25

Audio: No

Format: QuickTime, Photo JPEG 100%, progressive scan, square pixels

File size: 282.3M


Capture format: QuickTime Animation

Frame size: 720x486

Codec: Photo - JPEG

Interlaced: Yes

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