Sirtuin enzyme and p53, artwork

Sirtuin enzyme and p53, artwork

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Credit: RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY

Caption: Sirtuin enzyme and p53. Computer artwork of a sirtuin (Sir2) enzyme (pink) bound to a p53 peptide (orange). Sir2 enzymes form a unique class of NAD(+)-dependent deacetylases that are required for diverse biological processes, including transcriptional silencing, regulation of apoptosis (programmed cell death), fat mobilisation, and lifespan regulation. NAD is shown as a stick model (centre). p53 is crucial in multicellular organisms, where it regulates the cell cycle (the means by which cells replicate) and prevents the proliferation of cells with damaged DNA.

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Keywords: artwork, binding, biochemical, biochemistry, bound, cell antigen, cell cycle, complex, complexed, illustration, metabolic, metabolism, molecular model, molecule, nad, nad-dependent deacetylase, p53, peptide, preventative, prevention, protein, proteins, proteomics, regulation, regulator, secondary structure, sir 2, sir-2, sir2, structure, tertiary structure, tumor suppressor, tumour suppressor protein

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