Credit: FRANCIS LEROY & MATHILDE VANSPEYBROUCK, BIOCOSMOS/SCIENCE PHOTO LIBRARY

Caption: Cancer-causing genetic mutation. Animation showing the role played by a genetic mutation that causes a form of cancer. A protooncogene that codes for a Ras protein mutates into an oncogene. This protein plays an intermediate role in the transfer of proliferating signal from the cell membrane to the nucleus. When operating normally, this protein acts only briefly. The mutation shown here has caused the receptor (yellow, upper right) for a growth factor (red) to remain constantly active, even if the signal has disappeared. The result is the continuous sending of proliferating signals (centre, red and blue dots) to the nucleus (lower centre), resulting in cancer. For this animation with labels, see K004/2694. For an animation of the normal, non-mutated receptor, see K004/2693.

Release details: Model release not required. Property release not required.

Keywords: animated, animation, biological, biology, cancer, cell biology, cell membrane, cell nucleus, cytology, diagram, dna, gene, genes, genetic, genetics, growth factor, illustration, mutated, mutation, oncogene, oncology, proliferating signal, protooncogene, ras protein, receptor, signal transmission, signaling, signalling

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Cancer-causing genetic mutation

K004/2692 Rights Managed

Downloadable master

Duration: 00:00:46.21

Frame size: 1280x720

Frame rate: 25

Audio: No

Format: QuickTime, Photo JPEG 100%, progressive scan, square pixels

File size: 238.1M

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Capture format: QuickTime Animation

Codec: H.264

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