Endotoxin testing

Endotoxin testing

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Credit: FOOD & DRUG ADMINISTRATION/SCIENCE PHOTO LIBRARY

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Caption: Endotoxin testing. Scientist holding negative (top) and positive (bottom) samples from a test for bacterial endotoxin. Endotoxin is a component of the outer membrane of the cell wall of Gram negative bacteria. It can be present even after a sample has been sterilised. If injected into the body, it causes fever. To ensure that medicines or medical devices are endotoxin free, they are tested by mixing a sample with an extract from the blood of the horseshoe crab (Limulus polyphemus). This extract, limulus amebocyte lysate (LAL), causes clotting in the presence of endotoxin.

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Keywords: adult, american, bacterial, bacterium, biochemical, biochemistry, black-and-white, blood extract, clotting, endotoxin, gram negative bacteria, historical, history, horseshoe crab, human, laboratory, lal, limulus amebocyte lysate, limulus polyphemus, male, man, medical, medicine, monochrome, negative, north america, one person, people, positive, pyrogen test, reaction, safety, sample, scientist, test, test tube, testing, united states, usa

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