Formation of amyloid beta protein

Formation of amyloid beta protein

C021/7500 Rights Managed

Request low-res file

530 pixels on longest edge, unwatermarked

Request/Download high-res file

Uncompressed file size: 50.7MB

Downloadable file size: 1.9MB

Price image Pricing

Please login to use the price calculator


Credit: RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY

Caption: Formation of amyloid beta protein, computer artwork. Amyloid beta protein is the primary component of amyloid plaques found in the brains of Alzheimer's patients. It is created by the cleavage of the transmembrane protein amyloid precursor protein (APP, grey and red, centre). The cleavage is carried out by two enzymes. First the enzyme beta secretase (yellow) cleaves the protein to give a soluble fragment (sAPPb) and a membrane-bound fragment (CTFb). Then the enzyme gamma secretase (beige, left) cleaves the membrane-bound fragment to give a beta amyloid peptide (red) and a membrane-bound C-terminal fragment (AICD). Beta amyloid peptides are 'sticky' and accumulate into plaques (top right).

Release details: Model release not required. Property release not required.

Keywords: aicd, amyloid beta, amyloid precursor protein, amyloidogenic pathway, app, artwork, asp2, aspartyl protease 2, bace1, beta amyloid, beta-secretase 1, beta-site amyloid precursor protein cleaving enzyme 1, beta-site app cleaving enzyme 1, biochemical, biochemistry, biological, biology, cell membrane, cleavage, ctfb, disease mechanism, enzyme, gamma secretase, illustration, integral membrane protein, medical, medicine, memapsin-2, membrane-associated aspartic protease 2, molecular, molecule, nobody, pathological, pathology, plaque, plaque-forming pathway, protease, protein, sappb, structure, transmembrane protein

Licence fees: A licence fee will be charged for any media (low or high resolution) used in your project.