Credit: FRANCIS LEROY & MICHAEL PIERARD, BIOCOSMOS/SCIENCE PHOTO LIBRARY

Caption: Cocaine mechanism of action. Animation showing the normal function of dopamine at a synapse (junction between two nerve cells) and then what happens when cocaine is present. A nerve signal travels (from left to right) towards the presynaptic membrane (centre left) of the neuron (nerve cell), where it triggers the release of the neurotransmitter dopamine (blue ovals). The dopamine molecules bind to receptors (yellow) on the postsynaptic membrane (centre right), opening ion channels that transport sodium ions (red) into the cell. This propagates the nerve signal. The dopamine is released from the receptors and taken up by the the presynaptic cell to be recycled. Cocaine (green) blocks this reuptake, leading to an accumulation of dopamine in the synaptic cleft. This is what causes the pleasurable feeling that cocaine users experience. Over time this increased dopamine level downregulates the number of postsynaptic receptors, meaning that more of the drug is needed to get the same experience. For this animation without text see K004/0313.

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Keywords: acetylcholine, agonist, animated, animation, biochemical, biochemistry, black background, cocaine, dat, dopamine, dopamine transporter, drug, illegal, illicit, inhibitor, inhibitory, labeled, labelled, labels, mechanism of action, neuroscience, neurotransmitter, receptor, recreational, reuptake, stimulant, synapse, synaptic cleft, text

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Cocaine mechanism of action

K004/0312 Rights Managed

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Duration: 00:00:47.1

Frame size: 1920x1080

Frame rate: 25

Audio: No

Format: QuickTime, Photo JPEG 100%, progressive scan, square pixels

File size: 478.2M

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Capture format: QuickTime Animation

Codec: H.264

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