Credit: FRANCIS LEROY & M. MARTINACHE, BIOCOSMOS/SCIENCE PHOTO LIBRARY

Caption: Type I hypersensitivity response, animation. This is an allergic response caused by reexposure to a specific allergen, or antigen. The first time the antigen is encountered it is captured by an antigen presenting cell, which presents it to B lymphocytes and CD4 T helper lymphocytes. These are types of white blood cell. The T helper lymphocytes stimulate the B lymphocytes to produce immunoglobulin E (IgE) antibodies that specifically bind the antigen. These antibodies attach to mastocytes, or mast cells, sensitising them. The next time that the antigen is encountered it is bound by antibodies on the mast cell surface. Binding cross-links two IgE molecules, which causes the degranulation of the mast cell. Degranulation is the release of chemicals, including histamine, which cause the symptoms of an allergic reaction.

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Keywords: allergen, allergic, allergy, animated, animation, antibody, antigen, antigen presenting cell, apc, b cell, b lymphocyte, biological, biology, black background, cd4, ige, immune cells, immune response, immune system, immunity, immunoglobulin e, immunological, immunology, label, labeled, labelled, labels, mast cell, mastocyte, re-exposure, reaction, reexposure, t cell, t lymphocyte, text, type i hypersensitivity, white blood cell

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Type I hypersensitivity response

K004/3614 Rights Managed

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Duration: 00:00:44.24

Frame size: 1920x1080

Frame rate: 25

Audio: No

Format: QuickTime, Photo JPEG 100%, progressive scan, square pixels

File size: 445.9M

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Capture format: QuickTime Animation

Codec: H.264

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