Illustration depicting a Valley Fever spherule bursting inside the lungs. Valley fever (Coccidioidomycosis) is a fungal disease endemic to certain parts of the American Southwest. It can lie dormant during long dry spells, then develop as a mold which breaks off into airborne spores. Once inhaled, the spores grow into spherules which continue to enlarge until they burst as shown. Hundreds of endospores are released, each of which can grow into a new spherule, further spreading the disease.
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