Irritable bowel syndrome drug

Irritable bowel syndrome drug

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Credit: DR P. MARAZZI/SCIENCE PHOTO LIBRARY

Caption: Constella capsule. Constella is the trade name for Linaclotide, a drug approved for treating abdominal pain in irritable bowel syndrome (IBS) with constipation. Linaclotide is a peptide which is not absorbed into the bloodstream but acts locally, binding to guanylate cyclase C receptors found in the walls of the intestine. This results in a reduction abdominal pain, and an increase in the amount of fluid in the intestine, which softens the stools and facilitates their movement through the bowel.

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