Triose phosphate isomerase (TPI) molecule, computer model. TPI, an enzyme, is essential for glycolysis and catalyses the reversible interconversion of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. This conversion allows all products of the initial glucose molecule to be further metabolised for maximum energy yield. In humans, deficiencies in TPI are associated with a progressive, severe neurological disorder called triose phosphate isomerase deficiency.
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