Gerstmann-Straussler-Scheinker syndrome. Immunohistochemistry light micrograph of a section through the cerebellum of a brain affected by Gerstmann-Straussler-Scheinker syndrome (GSS), showing plaques (sepia). GSS is a rare fatal neurodegenerative disease and a form of transmissible spongiform encephalopathy (TSE), which affect the brain. TSEs are thought to be transmitted by virus-like prions (misfolded proteins) within the brain that cause vacuoles and plaques to form, making the brain spongy and killing off the tissue. Symptoms include dementia and sudden muscle contractions, leading to death.
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