Genetically engineered t-cell

Genetically engineered t-cell

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Credit: Carol and Mike Werner/SCIENCE PHOTO LIBRARY


Caption: Genetically engineered T-cell attacking a cancer cell. Chimeric antigen receptors (CAR) are genetically engineered from specific monoclonal antibodies. These fusion receptors are comprised of a targeting portion (in this case, a single chain antibody), coupled via a hinge and transmembrane element to a modular signalling domain. This is a third generation CAR in which signalling and additional stimulation is provided by a T-cell receptor complex, CD28 and a tumour necrosis factor receptor (TNFr). Contact between the MHC peptide and the TCR triggers the release and exocytosis of granzymes from cytotoxic granules. along with exogenous administration of IL-2 to further boost their anti-cancer activity.

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Keywords: antibody, apoptosis, cancer, car, cell, chimeric antigen receptor, disease, fusion receptor, genetic engineering, illustration, medical, medication, medicine, monoclonal antibody, necrosis factor, receptor, research, signaling domain, t-cell, treatment, tumor

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