Monoclonal antibody IgG2a

Monoclonal antibody IgG2a

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Credit: ALFRED PASIEKA/SCIENCE PHOTO LIBRARY

Caption: Antibody molecule. Molecular structure of a monoclonal human immunoglobulin (IgG2a). IgG antibodies are composed of 2 long heavy chains and 2 shorter light chains. This antibody adopts a T-shape: the arms of the T make up the Fab or antigen binding region, while the base part or Fc region plays a role in interacting with the immune system. Atoms are represented as sticks and ribbons and are rainbow-colour-coded. Under the name of Denosumab this type of human monoclonal antibody is used for the treatment of osteoporosis, treatment-induced bone loss and bone metastases. Medication trade names include Prolia and Xgeva.

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