CPHPC anti-amyloid drug molecule

CPHPC anti-amyloid drug molecule

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Credit: RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY

Caption: CPHPC anti-amyloid drug molecule. Molecular model of the anti-amyloid drug CPHPC (C12.H15.N.O3). Atoms are represented as spheres and are colour-coded: carbon (grey), hydrogen (white), nitrogen (blue) and oxygen (red). CPHPC is a proline-derived small molecule able to strip amyloid P (AP) from deposits by reducing levels of circulating serum amyloid P (SAP). It can be used to help treat amyloidosis, a disease caused by a build-up of amyloid (insoluble fibrous protein aggregates) in body tissues that leads to organ failure. Treatment combining CPHPC with an antibody has been shown to result in the rapid breakdown of deposited amyloid in humans.

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