K-Ras benzamidine and GTP complex

K-Ras benzamidine and GTP complex

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Credit: RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY

Caption: K-Ras benzamidine and GTP complex. Computer model showing the structure of a molecule of the K-Ras oncogene protein in complex with benzamidine (centre, spheres) and GTP (spheres, lower right). Ras proteins are involved in transmitting signals within cells. They are GTPase enzymes - they bind and hydrolyze GTP. Mutations in the K-Ras gene is an essential step in the development of many cancers, therefore this protein is classed as an oncogene protein. Ras inhibitors such as benzamidine are being studied as a treatment for cancer.

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