Credit: INTELECOM /SCIENCE PHOTO LIBRARY

Caption: As an action potential reaches the terminal end bulb of the axon, calcium enters the axon triggering the release of neurotransmitters to the muscle. As an action potential reaches the terminal end bulb, which is a bulbous swelling at the end of the nerve axon, voltage-gated calcium channels open, leading to an influx of calcium. In the presence of calcium, vesicles containing neurotransmitters dock or fuse to the plasma membrane of the axon terminals. Snare complex proteins stabilize the fusing of vesicles to the membrane during this process which, in turn, brings about exocytosis and the release of the neurotransmitter acetylcholine. The acetylcholine diffuses across the synaptic cleft and binds to a receptor on the muscle fiber ?s cell membrane, or sarcolemma. The binding of acetylcholine to receptors depolarizes the sarcolemma. An action potential is then generated _ _leading to muscle contraction.

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Keywords: acetylcholine, action potential, axon end bulb, axon terminal, calcium, calcium channel, exocytosis, muscle, muscular system, nerve, nervous system, neuromuscular junction, neurotransmitter, plasma membrane, sarcolemma, synaptic cleft

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Calcium enters axon

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Duration: 00:01:11.03

Frame size: 1920x1080

Frame rate: 29.97

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