Lipoprotein and PCSK9 bound to receptor

Lipoprotein and PCSK9 bound to receptor

C026/3517 Rights Managed

Request low-res file

530 pixels on longest edge, unwatermarked

Request/Download high-res file

Uncompressed file size: 53.6MB

Downloadable file size: 2.2MB

Price image Pricing

Please login to use the price calculator


Credit: MAURIZIO DE ANGELIS/SCIENCE PHOTO LIBRARY

Caption: Lipoprotein and PCSK9 bound to receptor. Computer illustration of a low-density lipoprotein (LDL), or 'bad' cholesterol, molecule (round) and a molecule of the enzyme proprotein convertase subtilisin/kexin type 9 (PCSK9, blue) bound to an LDL receptor (LDLR) protein (Y-shaped), with red blood cells (erythrocytes, discs) in a blood vessel (not to scale). When there are high levels of LDL cholesterol in the blood it builds up on the sides of blood vessels hardening them, a condition named atherosclerosis. This narrows the blood vessels and may block them. LDL receptors recognise and bind to LDL molecules to remove them from the bloodstream. When PCSK9 binds to an LDLR, the receptor is destroyed along with the LDL particle. But if PCSK9 does not bind, the receptor can return to the surface of the cell and remove more cholesterol. PCSK9 inhibitor drugs reduce the amount of cholesterol in the blood by improving the liver's ability to recycle LDLRs.

Release details: Model release not required. Property release not required.

Keywords: 3-dimensional, 3d, apo-b, apolipoprotein, artwork, bad cholesterol, binding, biochemical, biochemistry, blood system, blood vessel, bloodstream, bound, cell surface, cells, cholesterol, circulation, enzyme, erythrocyte, erythrocytes, esterified, healthcare, illustration, ldl, ldlr, lipoprotein, lipoproteins, low density, low-density lipoprotein, medical, medicine, molecule, molecules, no-one, nobody, particle, particles, pcsk9, phospholipid, phospholipids, proprotein convertase subtilisin/kexin type 9, protein, proteins, receptor, receptors, red blood cell, removal, removing, structure, three dimensional, unesterified, vesicle

Licence fees: A licence fee will be charged for any media (low or high resolution) used in your project.