Riluzole action, Illustration

Riluzole action, Illustration

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Credit: Carol and Mike Werner/SCIENCE PHOTO LIBRARY


Caption: Illustration of the action of riluzole. Riluzole is a neuroprotective drug that blocks the action of the neurotransmitter glutamate in the central nervous system. It inhibits the release of glutamic acid from neurons also blocks some of the postsynaptic effects of glutamic acid by blocking N-methyl-D-aspartate (NMDA) receptors. This drug is used to slow the progress of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease). Labelled are axon terminal (large bell shape), sodium channel (reddish squares), glutamate release (bottom of axon), AMPA receptor (blue under axon), NMDA receptor (red under axon), glia cell (faint yellow on left), voltage-sensitive calcium channel (green), and large motor neuron at bottom. The molecular model of riluzole is shown on the right: Black=carbon, white=hydrogen, red=oxygen, blue=nitrogen, green=fluorine, yellow=sulfur.

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Keywords: als treatment, ampa receptor, amyotrophic lateral sclerosis, artwork, axon terminal, ball and stick, central nervous system, diagram, drug, effects, glia cell, glutamate release, glutamic acid, glutamine, illustration, large motor neuron, medical, medication, medicine, molecular model, molecule, motor neuron, n-methyl-d-aspartate, neuron, neuroprotective drug, neurotransmitter, nmda, nmda receptor, receptor, riluzole, sodium channel, synapse, voltage-sensitive calcium channel

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