Trichostatin A molecule, illustration

Trichostatin A molecule, illustration

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Credit: Scimat/SCIENCE PHOTO LIBRARY

Caption: Molecular model of Trichostatin A. Trichostatin A (TSA) is an organic compound that serves as an antifungal antibiotic and selectively inhibits the class I and II mammalian histone deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., Sirtuins). TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones (histone deacetylases, HDAC) and therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin. It is a member of a larger class of histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Thus, TSA has some potential as an anti-cancer drug. Formula: C17 H22 N2 O3; Mol. mass: 302.37 g/mol; Carbon: gray, Hydrogen: greenish; Nitrogen: blue; Oxygen: red.

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Keywords: anti-cancer drug, apoptosis, cancer, chemical, chemistry, chromatin, drug, epigenetic, histone deacetylase inhibitors, histones, medical, medication, medicine, model, molecular, molecular model, molecule, science, transcription factors, treatment, trichostatin a

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