Osteosarcoma cells, light micrograph

Osteosarcoma cells, light micrograph

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Credit: NANCY KEDERSHA/SCIENCE PHOTO LIBRARY

Caption: Osteosarcoma cells. Immunofluorescence light micrograph of human osteosarcoma cells responding to the drug (clotrimazole) that induces energy starvation. The protein stains are for succinylated WGA lectin (green), SIGMAR1 (red), and TIAR (blue). SIGMAR1 functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions. TIAR is an RNA binding protein that regulates alternative splicing in the nucleus, and stress granule formation in the cytoplasm. Succinylated WGA binds sugars that are found on the nuclear envelope. Magnification: x1030 when printed at 10 centimetres wide.

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Keywords: alternative splicing, biochemical, biochemistry, biological, bone cancer, cancer, cancerous, cell, cell biology, cell culture, cells, cellular, clotrimazole, cytological, cytology, cytoskeleton, drug, endoplasmic reticulum, energy starvation, fluorescence, fluorescent, immunofluorescence, lectin, light micrograph, light microscope, lipid transport, lm, malignancy, malignant, medical, medicine, no-one, nobody, nuclear envelope, oncology, organelles, osteosarcoma, protein, proteins, rna binding protein, sigmar1, stress, stress granule formation, stressed, succinylated wga, sugar binding, tiar

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