Tumour necrosis factor-alpha

Tumour necrosis factor-alpha

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Caption: Tumour necrosis factor-alpha (TNF-alpha), computer model. This molecule is composed almost entirely of anti-parallel beta-sheets (blue). This protein generally exists as a trimer (a molecule consisting of 3 identical smaller molecules, seen here). It is released by white blood cells, mainly macrophages, during inflammatory immune responses, and acts as a signalling molecule. Its release is triggered by injury or bacterial endotoxins. One of its actions is to kill tumour cells, hence its name. TNF-alpha is also involved in a number of inflammatory diseases, including rheumatoid arthritis, psoriasis and Crohn's disease.

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Keywords: artwork, beta-sheet, biochemistry, cachectin, cachexin, chemical, chemistry, computer artwork, computer model, crohn's disease, cytokine, defense, host defence, illustration, immune response, immune system, medical, medicine, molecular, molecule, pro inflammatory, protein, psoriasis, rheumatoid arthritis, sheeets, structural, structure, tnf, trimer, tumor, tumour necrosis factor-alpha

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