Botulinum type B neurotoxin

Botulinum type B neurotoxin

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Credit: LAGUNA DESIGN/SCIENCE PHOTO LIBRARY

Caption: Botulinum type B neurotoxin, molecular model. This powerful toxin, produced by the bacterium Clostridium botulinum, enters nerve cells and prevents release of neurotransmitters. This destroys communication pathways between nerve cells and leads to muscle paralysis, respiratory failure and death. This type B toxin has been marketed under the trade names Neurobloc (EU) and Myobloc (US) to treat cervical dystonia, a movement disorder affecting the neck muscles. In this model, solid colours represent the secondary structure of the protein (spiral ribbons are alpha helices; arrows are beta sheets), and the faded tubular structure behind represents the individual atoms and bonds.

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Keywords: alpha helix, bacteria, bacteriology, bacterium, beta sheets, biochemical, biochemistry, biological, biology, botulinum type b, c. botulinum, chemical, chemistry, clostridium botulinum, compound, compounds, disease, helices, illustration, medical, medicinal, medicine, microbiological, microbiology, molecular, molecular model, molecule, molecules, myobloc, neurobloc, neurotoxic, neurotoxin, protein, proteins, secondary structure, sheet, structure, toxin, toxins

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