Methotrexate cancer drug

Methotrexate cancer drug

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Credit: NATIONAL CANCER INSTITUTE/SCIENCE PHOTO LIBRARY

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Caption: Methotrexate cancer drug. Bottle containing pills of the antifolate drug methotrexate. It treats cancer by inhibiting the metabolism of folic acid (vitamin B9), which is necessary for the production and maintenance of new cells. Methotrexate was first used in the late 1940s by Dr. Sidney Farber, who administered it to a small group of very ill leukaemic children. The vast improvement in Farber's patients heralded the era of cancer chemotherapy in modern medicine and led to methotrexate being approved for widespread use in 1953.

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